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Electrostatic interactions dominate the catalytic contribution of Arg39 in 4-oxalocrotonate tautomerase

Journal of the American Chemical Society, ISSN: 0002-7863, Vol: 126, Issue: 40, Page: 12726-12727
2004
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Article Description

The synthesis and kinetic parameters of a comprehensive set of 4-OT analogues with arginine (X = NH2+) to citrulline (X = O) substitutions at positions 11, 39, and 61 are reported. These data suggest that the main contribution of Arg39' ' to catalysis is by electrostatic stabilization of the anionic transition state leading to intermediate 2, and not by hydrogen bonding.

Bibliographic Details

Metanis, Norman; Brik, Ashraf; Dawson, Philip E; Keinan, Ehud

American Chemical Society (ACS)

Chemical Engineering; Chemistry; Biochemistry, Genetics and Molecular Biology

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