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Functionalization of peptides and proteins by Mukaiyama aldol reaction

Journal of the American Chemical Society, ISSN: 0002-7863, Vol: 132, Issue: 28, Page: 9546-9548
2010
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Article Description

The scope of the catalyst-free water-based Mukaiyama aldol reaction was explored through its application to the site-selective functionalization of N-terminal aldehydes of peptides and proteins. Various functional groups were introduced under mild and environmentally friendly conditions, with the first demonstration of aldol C-C bond formation in protein labeling studies. The efficiency and speed achieved in protein labeling can be of special interest in chemical biology studies. © 2010 American Chemical Society.

Bibliographic Details

Alam, Jenefer; Keller, Thomas H; Loh, Teck-Peng

American Chemical Society (ACS)

Chemical Engineering; Chemistry; Biochemistry, Genetics and Molecular Biology

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