PlumX Metrics
Embed PlumX Metrics

Synthesis of streptolydigin, a potent bacterial RNA polymerase inhibitor

Journal of the American Chemical Society, ISSN: 0002-7863, Vol: 132, Issue: 41, Page: 14394-14396
2010
  • 34
    Citations
  • 0
    Usage
  • 61
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Streptolydigin is a highly potent, broad-spectrum antibiotic produced by Streptomyces lydicus, which inhibits bacterial RNA polymerase. We describe the first synthesis of streptolydigin, which was assembled in a highly convergent and fully stereocontrolled fashion with a longest linear sequence of 24 steps starting from commercially available precursors. The assembly process entailed preparation of fully elaborated streptolic and ydiginic subunits of the natural product, followed by a highly efficient union in a three-step one-pot procedure, which included Dieckmann cyclization with a concomitant imide opening, Horner-Wadsworth-Emmons olefination, and desilylation. © 2010 American Chemical Society.

Bibliographic Details

Sergey V. Pronin; Sergey A. Kozmin

American Chemical Society (ACS)

Chemical Engineering; Chemistry; Biochemistry, Genetics and Molecular Biology

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know