α-synuclein induces both positive mean curvature and negative gaussian curvature in membranes
Journal of the American Chemical Society, ISSN: 0002-7863, Vol: 134, Issue: 5, Page: 2613-2620
2012
- 98Citations
- 4Usage
- 164Captures
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Metrics Details
- Citations98
- Citation Indexes98
- 98
- CrossRef93
- Usage4
- Abstract Views3
- Downloads1
- Captures164
- Readers164
- 164
Article Description
Using a combination of X-ray scattering, fluorescence correlation spectroscopy, coarse-grained molecular dynamics (MD) simulations and potential of mean force calculations, we have explored the membrane remodeling effects of monomeric α-synuclein (αS). Our initial findings from multiple approaches are that αS (1) causes a significant thinning of the bilayer and (2) stabilizes positive mean curvature, such that the maximum principle curvature matches that of synaptic vesicles, αS-induced tubules, and the synthetic lipid vesicles to which the protein binds most tightly. This suggests that αS binding to synaptic vesicles likely stabilizes their intrinsic curvature. We then show that αS induces local negative Gaussian curvature, an effect that occurs in regions of αS shown previously via NMR and corroborated by MD simulation to have significant conformational flexibility. The induction of negative Gaussian curvature, which has implications for all curvature-sensing and curvature-generating amphipathic α-helices, supports a hypothesis that connects helix insertion to fusion and fission of vesicles, processes that have recently been linked to αS function. Then, in an effort to explain these biophysical properties of αS, we promote an intrinsic curvature-field model that recasts long-range protein-protein interactions in terms of the interactions between the local curvature fields generated by lipid-protein complexes. © 2012 American Chemical Society.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84856763447&origin=inward; http://dx.doi.org/10.1021/ja208316h; http://www.ncbi.nlm.nih.gov/pubmed/22211521; https://pubs.acs.org/doi/10.1021/ja208316h; http://repository.cmu.edu/physics/202; http://repository.cmu.edu/cgi/viewcontent.cgi?article=1201&context=physics; http://pubs.acs.org/doi/abs/10.1021/ja208316h
American Chemical Society (ACS)
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