Two-phase synthesis of (-)-taxuyunnanine D
Journal of the American Chemical Society, ISSN: 1520-5126, Vol: 136, Issue: 13, Page: 4909-4912
2014
- 91Citations
- 183Captures
- 3Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations91
- Citation Indexes91
- 91
- CrossRef88
- Captures183
- Readers183
- 183
- Mentions3
- Blog Mentions2
- Blog2
- References1
- Wikipedia1
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Academia–industry collaboration in the route optimization of taxadienone
Reaction scale-up: We made ~2 g of taxadienone whereas AMRI made ~10 g. Reaction yields: Please see the figure below. Our laboratory is engaged in many collaborations with industrial groups, including LEO Pharma, Bristol-Myers Squibb, and Sigma-Aldrich, and in most cases, our industrial partner has a project goal toward which we provide expertise and in-house research findings.
Article Description
The first successful effort to replicate the beginning of the Taxol oxidase phase in the laboratory is reported, culminating in the total synthesis of taxuyunnanine D, itself a natural product. Through a combination of computational modeling, reagent screening, and oxidation sequence analysis, the first three of eight C-H oxidations (at the allylic sites corresponding to C-5, C-10, and C-13) required to reach Taxol from taxadiene were accomplished. This work lays a foundation for an eventual total synthesis of Taxol capable of delivering not only the natural product but also analogs inaccessible via bioengineering. © 2014 American Chemical Society.
Bibliographic Details
American Chemical Society (ACS)
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