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Ru(II)-catalyzed cycloadditions of 1,6-heptadiynes with alkenes: New synthetic potential of ruthenacyclopentatrienes as biscarbenoids in tandem cyclopropanation of bicycloalkenes and heteroatom-assisted cyclocotrimerization of 1,6-heptadiynes with heterocyclic alkenes

Journal of the American Chemical Society, ISSN: 0002-7863, Vol: 122, Issue: 18, Page: 4310-4319
2000
  • 120
    Citations
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  • 21
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Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    120
    • Citation Indexes
      120
  • Captures
    21

Article Description

The ruthenium(II)-catalyzed tandem cycloaddition of 1,6-heptadiynes with bicyclic alkenes, such as bicyclo[3.2.1]heptenones and norbornene derivatives, furnishes the 1:2 adducts between the diynes and two molecules of the bicycloalkenes together with common [2 + 2 + 2] cyclocotrimerization products. The structure of a representative tandem 1:2 adduct between dimethyl dipropargylmalonate and 2,4-dimethylbicyclo[3.2.1]-oct-6-en-3-one was unequivocally determined by X-ray analysis and was concluded to involve an unusual 1,2-dicyclopropylcyclopentene skeleton. On the basis of the spectroscopic analogy, the previously communicated structures of the tandem cycloadducts between the diynes and norbornene derivatives were corrected. The formation of the tandem double-cyclopropanation products from the diynes is chemical evidence of a biscarbenoid hybrid structure, 1,3,5- metallacyclopentatriene, of the corresponding 2,4-metallacyclopentadiene intermediates. The selectivity for the formation of the tandem cyclopropanation adducts was increased in the order of (η- CH)Ru(PPh)Cl > CpRu(cod)Cl > Cp*Ru(cod)Cl, indicative of the η ← η ring slippage of the cyclopentadienyl type ligands playing a key role in the tandem cyclopropanation. On the other hand, the normal [2 + 2 + 2] cyclocotrimerization between 1,6-heptadiynes and alkenes was selectively catalyzed by Cp*Ru(cod)Cl, in the case of cyclic or linear alkenes possessing heteroatoms at the allylic position. The latter heteroatom- assisted cyclocotrimerization was also catalyzed by a paramagnetic dinuclear ruthenium(III) complex, [Cp*RuCl], at lower temperature.

Bibliographic Details

Yoshihiko Yamamoto; Hideaki Kitahara; Ryuji Ogawa; Kenji Itoh; Hiroyuki Kawaguchi; Kazuyuki Tatsumi

American Chemical Society (ACS)

Chemical Engineering; Chemistry; Biochemistry, Genetics and Molecular Biology

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