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Design, semisynthesis, and evaluation of O-acyl derivatives of (-)-epigallocatechin-3-gallate as antitumor agents

Journal of Agricultural and Food Chemistry, ISSN: 0021-8561, Vol: 55, Issue: 15, Page: 6319-6324
2007
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Article Description

The partially purified catechin fraction isolated from green tea extract was treated with a variety of acylating agents (acyl anhydrides/chloride) to obtain (-)-epigallocatechin-3-gallate (EGCG) O-acyl derivatives in 20-25.4% yields. The (-)-EGCG O-acyl derivatives were characterized by physical data and spectral studies. These compounds were evaluated for their antitumor activity by use of a two-stage carcinogenesis model in 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cancer in Swiss albino mice. The study showed that there was a significant decrease in the antitumor activity with the increase in size and branching of the chain length of acyl groups. The results indicated that these O-acyl derivatives of (-)-EGCG have the potential to be developed as cancer chemopreventive agents. © 2007 American Chemical Society.

Bibliographic Details

Vyas, Sandeep; Sharma, Manu; Sharma, Pritam D; Singh, Tej V

American Chemical Society (ACS)

Chemistry; Agricultural and Biological Sciences

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