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Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7- methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl) piperidine-1-carboxamide (BMS-694153): A potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure

Journal of Medicinal Chemistry, ISSN: 0022-2623, Vol: 51, Issue: 16, Page: 4858-4861
2008
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Article Description

Calcitonin gene-related peptide (CGRP) has been implicated in the pathogenesis of migraine. Early chemistry leads suffered from modest potency, significant CYP3A4 inhibition, and poor aqueous solubility. Herein, we describe the optimization of these leads to give 4 (BMS-694153), a molecule with outstanding potency, a favorable predictive toxicology profile, and remarkable aqueous solubility. Compound 4 has good intranasal bioavailablity in rabbits and shows dose-dependent activity in validated in vivo and ex vivo migraine models. © 2008 American Chemical Society.

Bibliographic Details

Degnan, Andrew P; Chaturvedula, Prasad V; Conway, Charles M; Cook, Deborah A; Davis, Carl D; Denton, Rex; Han, Xiaojun; Macci, Robert; Mathias, Neil R; Moench, Paul; Pin, Sokhom S; Ren, Shelly X; Schartman, Richard; Signor, Laura J; Thalody, George; Widmann, Kimberly A; Xu, Cen; Macor, John E; Dubowchik, Gene M

American Chemical Society (ACS)

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics

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