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Synthesis and characterization of chiral N-O turns induced by α-aminoxy acids

Journal of Organic Chemistry, ISSN: 0022-3263, Vol: 66, Issue: 22, Page: 7303-7312
2001
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Article Description

Chiral α-aminoxy acids of various side chains were synthesized with high optical purity starting from chiral α-amino acids. The conformations of diamides 13a-e, 15, and 16 were probed by using NMR, FT-IR, and CD spectroscopic methods as well as X-ray crystallography. The right-handed turns with eight-membered-ring intramolecular hydrogen bonds between adjacent residues (called the N-O turns) were found to be preferred for D-aminoxy acid residues, and they were independent of the side chains. The rigid chiral N-O turns should have great potential in molecular design.

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