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Polyglycerol as a high-loading support for boronic acids with application in solution-phase Suzuki cross-couplings

Journal of Organic Chemistry, ISSN: 0022-3263, Vol: 67, Issue: 26, Page: 9452-9455
2002
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Article Description

In this paper, we describe the usage of a soluble high-loading polyglycerol support for functionalized boronic acids without further linker design. The quantitatively formed polyglycerol boron esters were subsequently employed in homogeneous Suzuki cross-coupling reactions to give high yields (84-91%) of functional biaryls with minimal amounts of the Pd catalyst (0.2 mol %). In situ precipitation and ultrafiltration were used as simple and effective purification protocols. Furthermore, the reaction conditions were optimized by the choice of the solvent and the catalyst.

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