Chemical modification of siRNA bases to probe and enhance RNA interference
Journal of Organic Chemistry, ISSN: 0022-3263, Vol: 76, Issue: 18, Page: 7295-7300
2011
- 89Citations
- 84Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations89
- Citation Indexes87
- 87
- CrossRef73
- Patent Family Citations1
- Patent Families1
- Policy Citations1
- Policy Citation1
- Captures84
- Readers84
- 84
Article Description
Considerable attention has focused on the use of alternatives to the native ribose and phosphate backbone of small interfering RNAs for therapeutic applications of the RNA interference pathway. In this synopsis, we highlight the less common chemical modifications, namely, those of the RNA nucleobases. Base modifications have the potential to lend insight into the mechanism of gene silencing and to lead to novel methods to overcome off-target effects that arise due to deleterious protein binding or mis-targeting of mRNA. © 2011 American Chemical Society.
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