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Formal synthesis of (±)-galanthamine and (±)-lycoramine using Rh(I)-Catalyzed [(3 + 2) + 1] cycloaddition of 1-Ene-vinylcyclopropane and CO

Journal of Organic Chemistry, ISSN: 1520-6904, Vol: 80, Issue: 3, Page: 1952-1956
2015
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Article Description

An efficient strategy using Rh(I)-catalyzed [(3 + 2) + 1] cycloaddition of 1-ene-vinylcyclopropane and CO as a key step to build the cis-hydrodibenzofuran skeleton has been developed and applied for the formal synthesis of (±)-galanthamine and (±)-lycoramine.

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