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Path dependence of three-phase or two-phase end points in fluid binary lipid mixtures

Journal of Physical Chemistry B, ISSN: 1520-6106, Vol: 113, Issue: 11, Page: 3431-3436
2009
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Article Description

The phase behavior of anionic/zwitterionic mixtures can be controlled by tuning the charge state of the anionic lipid. In the case of dioleoylphosphatidic acid (DOPA)/dioleoylphosphatidylcholine (DOPC) mixtures, demixing occurs either when DOPA is protonated or when DOPA:Ca complexes form. Herein it will be shown that the final end point, a three-phase or two-phase system, depends on the order in which the charge state is manipulated. The facile accessibility of different end points is a clear demonstration of the inherent flexibility of biological systems. © 2009 American Chemical Society.

Bibliographic Details

Lamberson, Emily R; Cambrea, Lee R; Rochet, Jean-Christophe; Hovis, Jennifer S

American Chemical Society (ACS)

Chemistry; Materials Science

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