A Physiologically Based Pharmacokinetic Model of Zidovudine (AZT) in the Mouse: Model Development and Scale-Up to Humans
Journal of Pharmaceutical Sciences, ISSN: 0022-3549, Vol: 86, Issue: 11, Page: 1223-1228
1997
- 7Citations
- 10Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations7
- Citation Indexes7
- CrossRef7
- Captures10
- Readers10
- 10
Article Description
After having been used in treating HIV infection for a decade, zidovudine (AZT) continues to be an essential component of antiretroviral regimens. Because antiviral responses and toxicity of AZT seem to be related to cells in specific target tissues, being able to understand and predict the distribution of AZT into different pharmacologically and toxicologically relevant tissues is therefore critically important to improving the efficacy and minimizing the toxicity of AZT therapy. This study was designed to develop a physiologically based pharmacokinetic model to help describe and predict the time course of AZT levels in different tissues. The model was developed in the mouse and then scaled up to predict human situations.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S002235491550422X; http://dx.doi.org/10.1021/js970243y; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030662154&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9383730; http://linkinghub.elsevier.com/retrieve/pii/S002235491550422X; https://dx.doi.org/10.1021/js970243y
American Geophysical Union (AGU)
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