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Dielectrophoretic force microscopy of aqueous interfaces

Langmuir, ISSN: 0743-7463, Vol: 21, Issue: 4, Page: 1436-1440
2005
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Article Description

A novel scanning probe microscopy technique has allowed dielectrophoretic force imaging with nanoscale spatial resolution. Dielectrophoresis (DEP) traditionally describes the mobility of polarizable particles in inhomogeneous alternating current (ac) electric fields. Integrating DEP with atomic force microscopy allows for noncontact imaging with the image contrast related to the local electric polarizability. By tuning the ac frequency, dielectric spectroscopy can be performed at solid/liquid interfaces with high spatial resolution. In studies of cells, the frequency-dependent dielectrophoretic force is sensitive to biologically relevant electrical properties, including local membrane capacitance and ion mobility. Consequently, dielectrophoretic force microscopy is well suited for in vitro noncontact scanning probe microscopy of biological systems.

Bibliographic Details

Brian P. Lynch; Al M. Hilton; Christopher H. Doerge; Garth J. Simpson

American Chemical Society (ACS)

Materials Science; Physics and Astronomy; Chemistry

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