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Evidence for leaflet-dependent redistribution of charged molecules in fluid supported phospholipid bilayers

Langmuir, ISSN: 0743-7463, Vol: 24, Issue: 23, Page: 13250-13253
2008
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Article Description

The asymmetric distribution of charged molecules between the leaflets of solid-substrate-supported phospholipid bilayers is studied using imaging ellipsometry, fluorescence microscopy, and numerical solutions of the Poisson-Boltzmann equation. Experiments are facilitated by the use of patterned substrates that allow for side-by-side comparison of lipid monolayers and supported bilayers. On silica surfaces, negatively charged lipid components are shown to be enriched in the outer leaflet of a supported bilayer system at modest salt concentrations. The approaches developed provide a general means for determining asymmetries of charged components in supported lipid bilayers. © 2008 American Chemical Society.

Bibliographic Details

Andrew P. Shreve; Michael C. Howland; Atul N. Parikh; Annapoorna R. Sapuri-Butti; Toby W. Allen

American Chemical Society (ACS)

Materials Science; Physics and Astronomy; Chemistry

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