Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers
Nano Letters, ISSN: 1530-6984, Vol: 8, Issue: 2, Page: 420-424
2008
- 522Citations
- 366Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations522
- Citation Indexes515
- 515
- CrossRef419
- Patent Family Citations7
- Patent Families7
- Captures366
- Readers366
- 366
Article Description
Nanoparticles with widely varying physical properties and origins (spherical versus irregular, synthetic versus biological, organic versus inorganic, flexible versus rigid, small versus large) have been previously noted to translocate across the cell plasma membrane. We have employed atomic force microscopy to determine if the physical disruption of lipid membranes, formation of holes and/or thinned regions, is a common mechanism of interaction between these nanoparticles and lipids. It was found that a wide variety of nanoparticles, including a cell penetrating pepide (MSI-78), a protein (TAT), polycationic polymers (PAMAM dendrimers, pentanol-core PAMAM dendrons, polyethyleneimine, and diethylaminoethyl-dextran), and two inorganic particles (Au-NH , SiO -NH ), can induce disruption, including the formation of holes, membrane thinning, and/or membrane erosion, in supported lipid bilayers. © 2008 American Chemical Society.
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