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Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo

Nano Letters, ISSN: 1530-6984, Vol: 9, Issue: 12, Page: 4412-4416
2009
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Article Description

We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy. © 2009 American Chemical Society.

Bibliographic Details

Lee, Seulki; Ryu, Ju Hee; Park, Kyeongsoon; Lee, Aeju; Lee, Seung-Young; Youn, In-Chan; Ahn, Cheol-Hee; Yoon, Soon Man; Myung, Seung-Jae; Moon, Dae Hyuk; Chen, Xiaoyuan; Choi, Kuiwon; Kwon, Ick Chan; Kim, Kwangmeyung

American Chemical Society (ACS)

Chemical Engineering; Chemistry; Materials Science; Physics and Astronomy; Engineering

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