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Nardosinanols A-I and lemnafricanol, sesquiterpenes from several soft corals, Lemnalia sp., Paralemnalia clavata, Lemnalia africana, and Rhytisma fulvum fulvum

Journal of Natural Products, ISSN: 0163-3864, Vol: 71, Issue: 3, Page: 375-380
2008
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Article Description

Ten new sesquiterpenes, nardosinanols A-I (1-9) and lemnafricanol (10), have been isolated from several Kenyan soft corals, i.e., from Lemnalia sp., Paralemnalia clavata, Lemnalia africana, and Rhytisma fulvum fulvum. The structures and relative stereochemistry of these compounds were elucidated by interpretation of MS, COSY (H-H correlations), HSQC, HMBC, and NOESY NMR spectroscopic experiments and in the case of 5 also by chemical transformation to compounds 11 and 12. Nine compounds (1-9) are based on the nardosinane skeleton (1-6 are nardosinanes and 7-9 nornardosinanes). Lemnafricanol (10) possesses a novel tricyclic skeleton. Compounds 3, 7, and 10 were found to be toxic to brine shrimp with LC values of 4.0, 0.35, and 0.32 μM, respectively. © 2008 American Chemical Society and American Society of Pharmacognosy.

Bibliographic Details

Bishara, Ashgan; Yeffet, Dina; Sisso, Mor; Shmul, Guy; Schleyer, Michael; Benayahu, Yehuda; Rudi, Amira; Kashman, Yoel

American Chemical Society (ACS)

Chemistry; Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Medicine

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