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Kadcotriones A-C: Tricyclic triterpenoids from kadsura coccinea

Journal of Natural Products, ISSN: 0163-3864, Vol: 76, Issue: 12, Page: 2350-2354
2013
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Article Description

Three new triterpenoids, kadcotriones A-C (1-3), together with the biogenetically related lanostane-type triterpenoid (4), were isolated from Kadsura coccinea. Compound 1 features a 12,14β-dimethyl 6/6/6-fused tricyclic skeleton, while 2 and 3 are characterized by a 6/6/5-ring system. Their structures were determined by NMR and electronic circular dichroism spectroscopic methods. Compounds 2 and 4 exhibited anti-HIV-1 activities with EC values of 30.29 and 54.81 μM, respectively. © 2013 The American Chemical Society and American Society of Pharmacognosy.

Bibliographic Details

Liang, Cheng-Qin; Shi, Yi-Ming; Li, Xing-Yao; Luo, Rong-Hua; Li, Yan; Zheng, Yong-Tang; Zhang, Hong-Bin; Xiao, Wei-Lie; Sun, Han-Dong

American Chemical Society (ACS)

Chemistry; Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Medicine

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