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A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against Human Immunodeficiency Virus-1 (HIV-1) integrase

Journal of Natural Products, ISSN: 0163-3864, Vol: 61, Issue: 1, Page: 145-148
1998
  • 141
    Citations
  • 0
    Usage
  • 39
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

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  • Citations
    141
  • Captures
    39
  • Mentions
    1
    • News Mentions
      1
      • News
        1

Most Recent News

Flavonoids quantification in Acer negundo L., extracts by HPLC analysis.

INTRODUCTION The genus Acer belongs to the family Aceraceae and the order Sapindaleae, comprising 180 species (Li et al., 2010). Maples (Acer spp.) are important

Article Description

Bioassay-directed chromatographic fractionation of an ethyl acetate extract of the leaves of Acer okamotoanum using HIV-1 integrase afforded a new acylated flavonol glycoside, quercetin 3-O-(26O-digalloyl)-β-D- galactopyranoside (1), together with six known flavonol glycosides and three known phenolic compounds. The structure of the new compound was determined by spectroscopic methods. The most active compounds were quercetin 3-O-(2 galloyl)-α-L-arabinopyranoside (6) and 1, which exhibited IC values of 18.1 ± 1.3 and 24.2 ± 6.6 μg/mL, respectively, against HIV-1 integrase.

Bibliographic Details

Hyoung Ja Kim; Eun-Rhan Woo; Cha-Gyun Shin; Hokoon Park

American Chemical Society (ACS)

Chemistry; Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Medicine

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