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Total synthesis of cyclomarin C

Organic Letters, ISSN: 1523-7060, Vol: 6, Issue: 16, Page: 2721-2724
2004
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Article Description

The total synthesis of cyclomarin C was accomplished through a convergent strategy from a tetrapeptide fragment and a tripeptide one. The developed methods to prepare the needed noncoded amino acids, the proper protection of peptide fragments, and identification of the optimum macrocylization site can be applied to further synthetic studies on other members of cyclomarins.

Bibliographic Details

Wen, Shi-Jun; Yao, Zhu-Jun

American Chemical Society (ACS)

Biochemistry, Genetics and Molecular Biology; Chemistry

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