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Synthesis of lactams via copper-catalyzed intramolecular vinylation of amides

Organic Letters, ISSN: 1523-7060, Vol: 7, Issue: 10, Page: 2035-2038
2005
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(Chemical Equation Presented) Copper-catalyzed intramolecular vinylation of iodoenamides were investigated for the first time. With Cul as the catalyst and N,W-dimethylethyienediamine as the ligand, a number of iodoenamides underwent cyclization in dioxane leading to the formations of five- to seven-membered lactams in moderate to excellent yields. © 2005 American Chemical Society.

Bibliographic Details

Hu, Tianshun; Li, Chaozhong

American Chemical Society (ACS)

Biochemistry, Genetics and Molecular Biology; Chemistry

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