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Efficient nucleophilic aromatic substitution between aryl nitrofluorides and alkynes

Organic Letters, ISSN: 1523-7060, Vol: 9, Issue: 14, Page: 2741-2743
2007
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Article Description

Equation Presented The nucleophilic aromatic substitution reaction between electron-deficient aryl fluorides and terminal alkynes is shown to be efficiently promoted by sodium bis(trimethylsilyl)amide as a base. Moderate to excellent yields of 2-ethynylnitrobenzene products can be obtained under mild conditions. © 2007 American Chemical Society.

Bibliographic Details

DeRoy, Patrick L; Surprenant, Simon; Bertrand-Laperle, Megan; Yoakim, Christiane

American Chemical Society (ACS)

Biochemistry, Genetics and Molecular Biology; Chemistry

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