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A novel diastereoselective multicomponent cascade reaction

Organic Letters, ISSN: 1523-7060, Vol: 12, Issue: 10, Page: 2230-2233
2010
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Article Description

A novel multicomponent cascade reaction led to the formation of a strained 3-azabicyclo[3.2.0]heptane derivative 4. The unstable ester 4 was reduced in a one-pot procedure to a stable alcohol 6. The formation of the bicyclic product is highly diastereoselective, predominantly affording one diastereoisomer. The obtained azabicycloheptanes are important pharmacophores. © 2010 American Chemical Society.

Bibliographic Details

Kriis, Kadri; Ausmees, Kerti; Pehk, Tõnis; Lopp, Margus; Kanger, Tõnis

American Chemical Society (ACS)

Biochemistry, Genetics and Molecular Biology; Chemistry

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