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Mild addition of nucleophiles to pyridine-N-oxides

Organic Letters, ISSN: 1523-7060, Vol: 13, Issue: 7, Page: 1840-1843
2011
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Article Description

A general and facile one-pot procedure for the synthesis of 2-substituted pyridines from the corresponding pyridine-N-oxides and nucleophiles is presented as a mild alternative to SAr chemistry. A variety of nucleophiles and heterocyclic-N-oxides participate effectively in this transformation, which uses the phosphonium salt, PyBroP, as a means of substrate activation. © 2011 American Chemical Society.

Bibliographic Details

Londregan, Allyn T.; Jennings, Sandra; Wei, Liuqing

American Chemical Society (ACS)

Biochemistry, Genetics and Molecular Biology; Chemistry

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