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De Novo synthesis of multisubstituted aryl amines using alkene cross metathesis

Organic Letters, ISSN: 1523-7060, Vol: 16, Issue: 7, Page: 1920-1923
2014
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Article Description

The olefin cross-metathesis reaction allows rapid access to 1,5-dicarbonyl intermediates which, upon treatment with a primary or secondary amine, allow the synthesis of a range of multisubstituted carbocyclic aryl amines. This de novo arene synthesis yields nonclassical substitution patterns in a regioselective and predictable approach that is compatible with several functional groups. © 2014 American Chemical Society.

Bibliographic Details

Tatton, Matthew R; Simpson, Iain; Donohoe, Timothy J

American Chemical Society (ACS)

Biochemistry, Genetics and Molecular Biology; Chemistry

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