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Applications of multicomponent reactions for the synthesis of diverse heterocyclic scaffolds

Organic Letters, ISSN: 1523-7060, Vol: 9, Issue: 21, Page: 4223-4226
2007
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Article Description

A four-component coupling process involving sequential reactions of aldehydes, primary amines, acid chlorides, and nucleophiles has been developed to prepare multifunctional substrates that may be employed in subsequent ring-forming reactions to generate a diverse array of functionalized heterocyclic scaffolds. This new approach to diversity-oriented synthesis was then applied to the first total synthesis of the isopavine alkaloid (±)-roelactamine. © 2007 American Chemical Society.

Bibliographic Details

Sunderhaus, James D; Dockendorff, Chris; Martin, Stephen F

American Chemical Society (ACS)

Biochemistry, Genetics and Molecular Biology; Chemistry

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