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New manufacturing procedure of cetirizine

Organic Process Research and Development, ISSN: 1083-6160, Vol: 16, Issue: 7, Page: 1279-1282
2012
  • 7
    Citations
  • 0
    Usage
  • 28
    Captures
  • 3
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    7
    • Citation Indexes
      7
  • Captures
    28
  • Mentions
    3
    • References
      3
      • Wikipedia
        3

Article Description

A new procedure for the manufacture of cetirizine dihydrochloride via the new intermediate 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)- N,N-dimethylacetamide dihydrochloride, synthesized by O-alkylation of 2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethanol with 2-chloro-N,N-dimethylacetamide, is elaborated. Hydrolysis of the resulting amide and subsequent salification provided cetirizine dihydrochloride. © 2012 American Chemical Society.

Bibliographic Details

József Reiter; Péter Trinka; László Pongó; Balázs Volk; Gyula Simig; Ferenc L. Bartha

American Chemical Society (ACS)

Chemistry

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