New manufacturing procedure of cetirizine
Organic Process Research and Development, ISSN: 1083-6160, Vol: 16, Issue: 7, Page: 1279-1282
2012
- 7Citations
- 28Captures
- 3Mentions
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Article Description
A new procedure for the manufacture of cetirizine dihydrochloride via the new intermediate 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)- N,N-dimethylacetamide dihydrochloride, synthesized by O-alkylation of 2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethanol with 2-chloro-N,N-dimethylacetamide, is elaborated. Hydrolysis of the resulting amide and subsequent salification provided cetirizine dihydrochloride. © 2012 American Chemical Society.
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