Endophenotypes of obsessive-compulsive disorder
Zeitschrift fur Psychiatrie, Psychologie und Psychotherapie, ISSN: 1661-4747, Vol: 61, Issue: 3, Page: 155-165
2013
- 2Citations
- 24Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
Obsessive-compulsive disorder (OCD) is a heritable condition that is associated with neuropsychological deficits. However, genetic underpinnings are difficult to identify and results have been inconsistent. Reasons for this difficulty may be that multiple genes are involved in the etiology of OCD and that the clinical phenotype of OCD is heterogeneous. The use of cognitive and biological endophenotypes was suggested as a resolution to these problems. Endophenotypes are state independent markers that exhibit a closer relation with genetic underpinnings than the clinical phenotype itself. In the current review, we discuss the current state of research on candidate endophenotypes for OCD and consider implications and future directions. In conclusion, several promising candidate endophenotypes for OCD have been identified, namely response inhibition, performance monitoring, and cognitive flexibility. © 2013 Verlag Hans Huber, Hogrefe AG, Bern.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84884272065&origin=inward; http://dx.doi.org/10.1024/1661-4747/a000154; https://econtent.hogrefe.com/doi/10.1024/1661-4747/a000154; http://psycontent.metapress.com/index/N843624841427459.pdf; https://econtent.hogrefe.com/doi/pdf/10.1024/1661-4747/a000154
Hogrefe Publishing Group
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