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Molecular pathology of human haemoglobin

Nature, ISSN: 0028-0836, Vol: 219, Issue: 5157, Page: 902-909
1968
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Article Description

The haemoglobin molecule is insensitive to replacements of most amino-acid residues on its surface, but extremely sensitive to even quite small alterations of internal non-polar contacts, especially those near the haems. Replacements at the contacts between α and β-subunits affect respiratory function. © 1968 Nature Publishing Group.

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