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Expression of a human gene for interferon in yeast

Nature, ISSN: 0028-0836, Vol: 293, Issue: 5835, Page: 717-722
1981
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Article Description

A DNA sequence coding for mature human leukocyte interferon D (LeIF-D) was linked with DNA fragments of the 5′-flanking sequences of the Saccharomyces cerevisiae (yeast) alcohol dehydrogenase I gene in a plasmid capable of autonomous replication and selection in both yeast and Escherichia coli. Yeast cells transformed by these plasmids synthesize up to 1 × 1O molecules of biologically active LeIF-D per cell. © 1981 Nature Publishing Group.

Bibliographic Details

Ronald A. Hitzeman; Frank E. Hagie; David V. Goeddel; Howard L. Levine; Gustav Ammerer; Benjamin D. Hall

Springer Science and Business Media LLC

Multidisciplinary

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