PlumX Metrics
Embed PlumX Metrics

Elucidation by FAB-MS of the structure of a new cardioactive peptide from Aplysia

Nature, ISSN: 0028-0836, Vol: 300, Issue: 5893, Page: 643-645
1982
  • 135
    Citations
  • 0
    Usage
  • 2
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

The nervous system and gut of Aplysia and other gastropod molluscs contain several classes of cardioactive peptides. In addition to their excitatory action on the heart, these peptides stimulate contractile activity in the gut, and modulate neurally induced contractions of somatic muscles. This report describes the purification and sequence determination by a combination of microprotein chemistry and fast atom bombardment mass spectrometry FAB-MS of one of these peptides. The sequenced peptide is a member of the small class of cardioactive peptides and was termed SCP. A peptide with identical properties to SCP has been found in several identified central neurones which innervate the gut. Here we report the structure of SCP as a C-terminally blocked peptide H-Met-Asn-Tyr-Leu-Ala-Phe-Pro-Arg-Met-NH Native and synthetic SCP have identical actions on molluscan muscle preparations with thresholds at around 10 M. © 1982 Nature Publishing Group.

Bibliographic Details

Howard R. Morris; Maria Panico; Andrew Karplus; Philip E. Lloyd; Bernhard Riniker

Springer Science and Business Media LLC

Multidisciplinary

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know