Elucidation by FAB-MS of the structure of a new cardioactive peptide from Aplysia
Nature, ISSN: 0028-0836, Vol: 300, Issue: 5893, Page: 643-645
1982
- 135Citations
- 2Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations135
- Citation Indexes135
- CrossRef135
- 128
- Captures2
- Readers2
Article Description
The nervous system and gut of Aplysia and other gastropod molluscs contain several classes of cardioactive peptides. In addition to their excitatory action on the heart, these peptides stimulate contractile activity in the gut, and modulate neurally induced contractions of somatic muscles. This report describes the purification and sequence determination by a combination of microprotein chemistry and fast atom bombardment mass spectrometry FAB-MS of one of these peptides. The sequenced peptide is a member of the small class of cardioactive peptides and was termed SCP. A peptide with identical properties to SCP has been found in several identified central neurones which innervate the gut. Here we report the structure of SCP as a C-terminally blocked peptide H-Met-Asn-Tyr-Leu-Ala-Phe-Pro-Arg-Met-NH Native and synthetic SCP have identical actions on molluscan muscle preparations with thresholds at around 10 M. © 1982 Nature Publishing Group.
Bibliographic Details
Springer Science and Business Media LLC
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know