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Sequence homology between retroviral reverse transcriptase and putative polymerases of hepatitis B virus and cauliflower mosaic virus

Nature, ISSN: 0028-0836, Vol: 305, Issue: 5937, Page: 827-829
1983
  • 331
    Citations
  • 0
    Usage
  • 33
    Captures
  • 0
    Mentions
  • 1
    Social Media
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Metrics Details

  • Citations
    331
  • Captures
    33
  • Social Media
    1
    • Shares, Likes & Comments
      1
      • Facebook
        1

Article Description

In infected cells, the RNA genomes of RNA tumour viruses are copied into DNA by a virus-encoded reverse transcriptase enzyme. This transfer of information from RNA into DNA was thought to be a unique feature of RNA tumour viruses, but recent results suggest it may be a more general strategy. Hepatitis B virus (HBV) has a double-stranded DNA genome, and it has recently been shown that the minus DNA strand of the HBV genome is copied from a plus-strand RNA template, leading to the suggestion that reverse transcription is central to the life cycle of HBV. More recently it has been suggested that the replication cycle of a plant virus, cauliflower mosaic virus (CaMV), includes a reverse transcription step. We report here the existence of amino acid sequence homology between retroviral reverse transcriptase and the putative polymerases of HBV and CaMV. © 1983 Nature Publishing Group.

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