Initiation of translation is impaired in E. coli cells deficient in 4.5S RNA
Nature, ISSN: 0028-0836, Vol: 325, Issue: 6101, Page: 281-284
1987
- 54Citations
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations54
- Citation Indexes54
- CrossRef54
- 53
- Captures12
- Readers12
- 12
Article Description
The 4.5S RNA of Escherichia coli is a small, stable RNA that is essential for cell growth but its function is not yet known. Its biosynthesis is stringently controlled, and it is processed by RNase P, a transfer RNA processing enzyme. To identify the biological role of the 4.5S species, we have characterized the physiological changes that occur when the bacterial cell is depleted of this RNA. We used a strain of E. coli in which synthesis of the 4.5S RNA can be turned off by removing an inducer of the lac operon, resulting in cell death. We report here that an early consequence of depriving the cell of 4.5S RNA is the accumulation of translationally-defective ribosomes, which maintain their ability to elongate polypeptide chains, but can no longer participate in the initiation of protein synthesis. © 1987 Nature Publishing Group.
Bibliographic Details
Springer Science and Business Media LLC
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