PlumX Metrics
Embed PlumX Metrics

A proteolytic system that compensates for loss of proteasome function

Nature, ISSN: 0028-0836, Vol: 392, Issue: 6676, Page: 618-622
1998
  • 240
    Citations
  • 0
    Usage
  • 45
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Proteolysis is essential for the execution of many cellular functions. These include removal of incorrectly folded or damaged proteins, the activation of transcription factors, the ordered degradation of proteins involved in cell cyde control, and the generation of peptides destined for presentation by class I molecules of the major histocompatibility complex. At, multisubunit protease complex, the proteasome, accomplishes these tasks. Here we show that in mammalian cells inactivation of the proteasome by covalent inhibitors allows the outgrowth of inhibitor-resistant cells. The growth of such adapted cells is apparently maintained by the induction of other proteolytic systems that compensate for the loss of proteasomal activity.

Bibliographic Details

Rickard Glas; Matthew Bogyo; John S. McMaster; Maria Gaczynska; Hidde L. Ploegh

Springer Science and Business Media LLC

Multidisciplinary

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know