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Cloning and characterization of an extracellular Ca-sensing receptor from bovine parathyroid

Nature, ISSN: 0028-0836, Vol: 366, Issue: 6455, Page: 575-580
1993
  • 2,470
    Citations
  • 0
    Usage
  • 317
    Captures
  • 3
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    2,470
    • Citation Indexes
      2,465
    • Patent Family Citations
      3
      • Patent Families
        3
    • Policy Citations
      2
      • Policy Citation
        2
  • Captures
    317
  • Mentions
    3
    • News Mentions
      2
      • News
        2
    • References
      1
      • Wikipedia
        1

Most Recent News

Promiscuous G-protein activation by the calcium-sensing receptor

Nature, Published online: 17 April 2024; doi:10.1038/s41586-024-07331-1 Structures of the human calcium-sensing receptor can be bound into complex with G proteins from three different Gα subtypes while maintaining G-protein-binding specificity.

Article Description

Maintenance of a stable internal environment within complex organisms requires specialized cells that sense changes in the extracellular concentration of specific ions (such as Ca). Although the molecular nature of such ion sensors is unknown, parathyroid cells possess a cell surface Ca-sensing mechanism that also rec-ognizes trivalent and polyvalent cations (such as neomycin) and couples by changes in phosphoinositide turnover and cytosolic Ca to regulation of parathyroid hormone secretion. The latter restores normocalcaemia by acting on kidney and bone. We now report the cloning of complementary DNA encoding an extracellular Ca -sensing receptor from bovine parathyroid with pharmacological and functional properties nearly identical to those of the native receptor. The novel & sim;120K receptor shares limited similarity with the metabotropic glutamate receptors and features a large extracellular domain, containing clusters of acidic aminoacid residues possibly involved in calcium binding, coupled to a seven-membrane-spanning domain like those in the G-protein-coupled receptor superfamily. © 1993 Nature Publishing Group.

Bibliographic Details

Edward M. Brown; Robert Butters; Olga Kifor; Gerardo Gamba; Daniela Riccardi; Michael Lombardi; Adam Sun; Matthias A. Hediger; Jonathan Lytton; Steven C. Hebert

Springer Science and Business Media LLC

Multidisciplinary

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