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Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin

Nature Neuroscience, ISSN: 1097-6256, Vol: 1, Issue: 8, Page: 668-674
1998
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Article Description

The biophysical properties of T-type voltage-gated calcium channels are well suited to pacemaking and to supporting calcium flux near the resting membrane potential in both excitable and non-excitable cells. We have identified a new scorpion toxin (kurtoxin) that binds to the α T-type calcium channel with high affinity and inhibits the channel by modifying voltage-dependent gating. This toxin distinguishes between α T-type calcium channels and other types of voltage-gated calcium channels, including α, α, α and α. Like the other α-scorpion toxins to which it is related, kurtoxin also interacts with voltage-gated sodium channels and slows their inactivation. Kurtoxin will facilitate characterization of the subunit composition of T-type calcium channels and help determine their involvement in electrical and biochemical signaling.

Bibliographic Details

Rosalind S.I. Chuang; Kenton J. Swartz; Howard Jaffe; Leanne Cribbs; Edward Perez-Reyes

Springer Science and Business Media LLC

Neuroscience

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