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Signal transduction and regulation in smooth muscle

Nature, ISSN: 0028-0836, Vol: 372, Issue: 6503, Page: 231-236
1994
  • 1,777
    Citations
  • 0
    Usage
  • 272
    Captures
  • 5
    Mentions
  • 31
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    1,777
  • Captures
    272
  • Mentions
    5
    • References
      4
      • 4
    • Blog Mentions
      1
      • 1
  • Social Media
    31
    • Shares, Likes & Comments
      31
      • Facebook
        31

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Review Description

Smooth muscle cells in the walls of many organs are vital for most bodily functions, and their abnormalities contribute to a range of diseases. Although based on a sliding-filament mechanism similar to that of striated muscles, contraction of smooth muscle is regulated by pharmacomechanical as well as by electromechanical coupling mechanisms. Recent studies have revealed previously unrecognized contractile regulatory processes, such as G-protein-coupled inhibition of myosin light-chain phosphatase, regulation of myosin light-chain kinase by other kinases, and the functional effects of smooth muscle myosin isoforms. Abnormalities of these regulatory mechanisms and isoform variations may contribute to diseases of smooth muscle, and the G-protein-coupled inhibition of protein phosphatase is also likely to be impor-tant in regulating non-muscle cell functions mediated by cytoplasmic myosin II. © 2002 Nature Publishing Group.

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