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Structural basis of cell-cell adhesion by cadherins

Nature, ISSN: 0028-0836, Vol: 374, Issue: 6520, Page: 327-337
1995
  • 1,008
    Citations
  • 0
    Usage
  • 316
    Captures
  • 3
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    1,008
    • Citation Indexes
      1,006
    • Patent Family Citations
      2
      • Patent Families
        2
  • Captures
    316
  • Mentions
    3
    • References
      2
      • Wikipedia
        2
    • Blog Mentions
      1
      • Blog
        1

Article Description

Crystal structures of the amino-terminal domain of N-cadherin provide a picture at the atomic level of a specific adhesive contact between cells. A repeated set of dimer interfaces is common to the structure in three lattices. These interactions combine to form a linear zipper of molecules that mirrors the linear structure of the intracellular filaments with which cadherins associate. This cell-adhesion zipper may provide a mechanism to marshal individual molecular adhesive interactions into strong bonds between cells. © 1995, Nature Publishing Group. All rights reserved.

Bibliographic Details

Shapiro, Lawrence; Fannon, Allison M.; Kwong, Peter D.; Thompson, Andrew; Lehmann, Mogens S.; Grübel, Gerhard; Legrand, Jean-François; Als-Nielsen, Jens; Colman, David R.; Hendrickson, Wayne A.

Springer Science and Business Media LLC

Multidisciplinary

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