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Essential role of Stat6 in IL-4 signalling

Nature, ISSN: 0028-0836, Vol: 380, Issue: 6575, Page: 627-630
1996
  • 1,336
    Citations
  • 0
    Usage
  • 297
    Captures
  • 3
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    1,336
  • Captures
    297
  • Mentions
    3
    • References
      3
      • Wikipedia
        3

Article Description

Interleukin-4(IL-4) is a pleiotropic lymphokine which plays an important role in the immune system. IL-4 activates two distinct signalling pathways through tyrosine phosphorylation of Stat6, a signal transducer and activator of transcription, and of a 170K protein called 4PS. To investigate the functional role of Stat6 in IL-4 signalling, we generated mice deficient in Stat6 by gene targeting. We report here that in the mutant mice, expression of CD23 and major histocompatibility complex (MHC) class II in resting B cells was not enhanced in response to IL-4. IL-4-induced B-cell proliferation costimulated by anti IgM antibody was abolished. The T-cell proliferative response was also notably reduced. Furthermore, production of Th2 cytokines from T cells as well as IgE and IgG1 responses after nematode infection were profoundly reduced. These findings agreed with those obtained in IL-4-deficient mice or using antibodies to IL-4 and the IL-4 receptor. We conclude that Stat6 plays a central role in exerting IL-4-mediated biological responses.

Bibliographic Details

Takeda, Kiyoshi; Tanaka, Takashi; Shi, Wei; Matsumoto, Makoto; Minami, Masashi; Kashiwamura, Shin-ichiro; Nakanishi, Kenji; Yoshida, Nobuaki; Kishimoto, Tadamitsu; Akira, Shizuo

Springer Science and Business Media LLC

Multidisciplinary

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