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A p300/CPB-associated factor that competes with the adenoviral oncoprotein E1A

Nature, ISSN: 0028-0836, Vol: 382, Issue: 6589, Page: 319-324
1996
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Article Description

The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A. Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase.

Bibliographic Details

Xiang Jiao Yang; Vasily V. Ogryzko; Jun Ichi Nishikawa; Bruce H. Howard; Yoshihiro Nakatani

Springer Science and Business Media LLC

Multidisciplinary

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