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Prognostic importance of the inflammation-based Glasgow prognostic score in patients with gastric cancer

British Journal of Cancer, ISSN: 0007-0920, Vol: 107, Issue: 2, Page: 275-279
2012
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Ali Husain Shilib Al-Shimmery1, Ahmed Abdul-Abbas Bayram2, RaheemTuama Obayes Al Mammori3, Noor S.K. Al-Khafaji4, Hussein O.M. Al-Dahmoshi5 1Subspecialty Physician in GIT and Hepatology, Babylon GIT

Article Description

Background: The inflammation-based Glasgow prognostic score (GPS) has been shown to be a prognostic factor for a variety of tumours. This study investigates the significance of the modified GPS (mGPS) for the prognosis of patients with gastric cancer. Methods: The mGPS (0=C-reactive protein (CRP)≤10 mg l, 1CRP10 mg l and 2CRP10 mg l and albumin35 g l) was calculated on the basis of preoperative data for 1710 patients with gastric cancer who underwent surgery between January 2000 and December 2007. Patients were given an mGPS of 0, 1 or 2. The prognostic significance was analysed by univariate and multivariate analyses. Results: Increased mGPS was associated with male patient, old age, low body mass index, increased white cell count and neutrophils, elevated carcinoembryonic antigen and CA19-9 and advanced tumour stage. Kaplan-Meier analysis and log-rank test revealed that a higher mGPS predicted a higher risk of postoperative mortality in both relative early-stage (stage I; P<0.001) and advanced-stage cancer (stage II, III and IV; P<0.001). Multivariate analysis demonstrated the mGPS to be a risk factor for postoperative mortality (odds ratio 1.845; 95% confidence interval 1.184-2.875; P=0.007). Conclusion: The preoperative mGPS is a simple and useful prognostic factor for postoperative survival in patients with gastric cancer. © 2012 Cancer Research UK All rights reserved.

Bibliographic Details

X. Jiang; N. Hiki; S. Nunobe; K. Kumagai; T. Kubota; S. Aikou; T. Sano; T. Yamaguchi

Springer Science and Business Media LLC

Medicine; Biochemistry, Genetics and Molecular Biology

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