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Mortality in cancer patients previously diagnosed with herpes zoster in the hospital setting: A nationwide cohort study

British Journal of Cancer, ISSN: 1532-1827, Vol: 112, Issue: 11, Page: 1822-1826
2015
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Article Description

Background:Herpes zoster (HZ) is associated with underlying immunodeficiency and may thereby predict mortality of subsequent cancer.Methods:By using Danish nationwide medical databases, we identified all cancer patients with a prior hospital-based HZ diagnosis during 1982-2011 (n=2754) and a matched cancer cohort without prior HZ (n=26 243). We computed adjusted mortality rate ratios (aMRRs) associating prior HZ with mortality following cancer.Results:Prior HZ was associated with decreased mortality within the year after cancer diagnosis (aMRR 0.87; 95% confidence interval (CI): 0.81-0.93), but not thereafter (aMRR 1.07; 95% CI: 0.99-1.15). However, prior HZ predicted increased mortality throughout the entire follow-up among patients aged <60 years (aMRR 1.39; 95% CI: 1.15-1.68) and those with disseminated HZ (aMRR 1.18; 95% CI: 1.01-1.37). The increased mortality rates were observed primarily for haematological and immune-related cancers.Conclusions:Overall, HZ was not a predictor of increased mortality following subsequent cancer.

Bibliographic Details

S. A.J. Schmidt; G. V. Sørensen; E. Horváth-Puhó; L. Pedersen; H. C. Schønheyder; H. T. Sørensen; N. Obel; K. L. Petersen

Springer Science and Business Media LLC

Medicine; Biochemistry, Genetics and Molecular Biology

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