Effect of nitric oxide on proliferation of human retina pigment epithelial cells
Eye, ISSN: 0950-222X, Vol: 14, Issue: 6, Page: 899-902
2000
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Article Description
Purpose. To investigate the effects of exogenous and endogenous nitric oxide (NO) on the proliferation of human retina pigment epithelial (RPE) cells. Methods. We stimulated cultured human RPE cells with 3-morphosydnomine (SIN-1) to analyse the effect of exogenous NO. Incubation with a cytokine cocktail (interleukin 1-β + interferon γ + tumour necrosis factor α) plus lipopolysaccharide (LPS) induced cells to synthesise NO endogenously. The cultures were then incubated for 48 h, after which the cells were stained with crystal violet and absorbance at 550 nm was measured spectrophotometrically. Results. SIN-1 inhibited human RPE cell proliferation, while haemoglobin, an NO inhibitor, almost completely blocked the inhibitory effect. On the other hand, treatment with the cytokine cocktail plus LPS did not inhibit RPE cell proliferation. Conclusion. These findings confirm that exogenous NO inhibits human RPE cell proliferation, while endogenous NO has no such blocking effect.
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