The prospects for polymorphisms shared between species
Heredity, ISSN: 1365-2540, Vol: 68, Issue: 3, Page: 263-276
1992
- 17Citations
- 32Captures
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Metrics Details
- Citations17
- Citation Indexes17
- CrossRef17
- 17
- Captures32
- Readers32
- 32
Article Description
Recent molecular evidence has shown that many MHC polymorphisms are not only shared between species but are in fact identical at the molecular level. Species that share these polymorphisms may be very distantly related & often diverged millions of generations ago. It is now known that this phenomenon is very unlikely to occur if the alleles are selectively neutral. A large number of other studies suggest, however, that this phenomenon of shared polymorphisms is very common & extends to many other loci beyond just the MHC/HLA complexes. These studies also suggest that some polymorphisms may be older than the MHC/HLA polymorphisms. The maintenance of these polymorphisms via overdominant & frequency-dependent selection is discussed. Strong levels of selection are required for overdominance to maintain shared polymorphisms but most studies of effective population size produce long-term estimates that are very small & would not permit the level of overdominant selection required to maintain these polymorphisms. Frequency-dependent selection can rhaintain them for longer with less ‘apparent’ equilibrium selection & might permit smaller effective sizes. The variance of allele frequencies is suggested to be one way to distinguish between these two selection models. © 1992 The Genetical Society of Great Britain.
Bibliographic Details
Springer Science and Business Media LLC
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