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Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1∗13:02-negative individuals of a Japanese population

Human Genome Variation, ISSN: 2054-345X, Vol: 3, Issue: 1, Page: 16001
2016
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Article Description

We herein report an association between TMEM132D and panic disorder (PD) in a Japanese population, evaluating the effects of HLA-DRB1∗13:02, which we previously reported as a susceptibility genetic factor for PD. SNPs in TMEM132D showed significant associations with PD in subjects without HLA-DRB1∗13:02 (rs4759997; P=5.02×10 â'6, odds ratio=1.50) but not in those with the HLA allele. TMEM132D might have a role in the development of PD in subjects without HLA-DRB1∗13:02.

Bibliographic Details

Shimada-Sugimoto, Mihoko; Otowa, Takeshi; Miyagawa, Taku; Khor, Seik-Soon; Omae, Yosuke; Toyo-Oka, Licht; Sugaya, Nagisa; Kawamura, Yoshiya; Umekage, Tadashi; Miyashita, Akinori; Kuwano, Ryozo; Kaiya, Hisanobu; Kasai, Kiyoto; Tanii, Hisashi; Okazaki, Yuji; Tokunaga, Katsushi; Sasaki, Tsukasa

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology

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