MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice
Laboratory Investigation, ISSN: 0023-6837, Vol: 95, Issue: 4, Page: 422-431
2015
- 340Citations
- 700Captures
- 69Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations340
- Citation Indexes340
- 340
- CrossRef328
- Captures700
- Readers700
- 700
- Mentions69
- News Mentions68
- News68
- References1
- Wikipedia1
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Article Description
MALDI Imaging mass spectrometry has entered the field of tissue-based research by providing unique advantages for analyzing tissue specimen in an unprecedented detail. A broad spectrum of analytes ranging from proteins, peptides, protein modification over small molecules, drugs and their metabolites as well as pharmaceutical components, endogenous cell metabolites, lipids, and other analytes are made accessible by this in situ technique in tissue. Some of them were even not accessible in tissues within the histological context before. Thereby, the great advantage of MALDI Imaging is the correlation of molecular information with traditional histology by keeping the spatial localization information of the analytes after mass spectrometric measurement. This method is label-free and allows multiplex analysis of hundreds to thousands of molecules in the very same tissue section simultaneously. Imaging mass spectrometry brings a new quality of molecular data and links the expert discipline of pathology and deep molecular mass spectrometric analysis to tissue-based research. This review will focus on state-of-the-art of MALDI Imaging mass spectrometry, its recent applications by analyzing tissue specimen and the contributions in understanding the biology of disease as well as its perspectives for pathology research and practice.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0023683722022875; http://dx.doi.org/10.1038/labinvest.2014.156; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84926339388&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/25621874; https://linkinghub.elsevier.com/retrieve/pii/S0023683722022875; https://dx.doi.org/10.1038/labinvest.2014.156
Elsevier BV
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