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Genetic alterations and their clinical implications in older patients with acute myeloid leukemia

Leukemia, ISSN: 1476-5551, Vol: 30, Issue: 7, Page: 1485-1492
2016
  • 103
    Citations
  • 0
    Usage
  • 102
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    103
  • Captures
    102
  • Mentions
    1
    • News Mentions
      1
      • 1

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Genetic alterations and their clinical implications in older patients with acute myeloid leukemia

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Article Description

A number of patient-specific and leukemia-associated factors are related to the poor outcome in older patients with acute myeloid leukemia (AML). However, comprehensive studies regarding the impact of genetic alterations in this group of patients are limited. In this study, we compared relevant mutations in 21 genes between AML patients aged 60 years or older and those younger and exposed their prognostic implications. Compared with the younger patients, the elderly had significantly higher incidences of PTPN11, NPM1, RUNX1, ASXL1, TET2, DNMT3A and TP53 mutations but a lower frequency of WT1 mutations. The older patients more frequently harbored one or more adverse genetic alterations. Multivariate analysis showed that DNMT3A and TP53 mutations were independent poor prognostic factors among the elderly, while NPM1 mutation in the absence of FLT3/ITD was an independent favorable prognostic factor. Furthermore, the status of mutations could well stratify older patients with intermediate-risk cytogenetics into three risk groups. In conclusion, older AML patients showed distinct genetic alterations from the younger group. Integration of cytogenetics and molecular mutations can better risk-stratify older AML patients. Development of novel therapies is needed to improve the outcome of older patients with poor prognosis under current treatment modalities.

Bibliographic Details

C. H. Tsai; H. A. Hou; J. L. Tang; C. C. Lin; W. C. Chou; M. H. Tseng; Y. C. Chiang; W. Tsay; M. Yao; C. C. Li; S. Y. Huang; B. S. Ko; C. Y. Chen; C. T. Lin; S. J. Wu; H. F. Tien; C. Y. Liu; S. C. Hsu; Y. Y. Kuo; M. C. Liu; C. W. Liu; L. I. Lin

Springer Science and Business Media LLC

Medicine; Biochemistry, Genetics and Molecular Biology

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