A subset of dopamine neurons signals reward for odour memory in Drosophila
Nature, ISSN: 0028-0836, Vol: 488, Issue: 7412, Page: 512-516
2012
- 438Citations
- 675Captures
- 2Mentions
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations438
- Citation Indexes438
- CrossRef438
- 400
- Captures675
- Readers675
- 638
- 37
- Mentions2
- News Mentions2
- News2
Most Recent News
Dopaminergic systems create reward seeking despite adverse consequences
Nature, Published online: 25 October 2023; doi:10.1038/s41586-023-06671-8 In Drosophila, a subpopulation of reward-encoding dopaminergic neurons antagonizes punishment-encoding neurons and can override punishment or hunger cues in favour of reward-seeking behaviour.
Article Description
Animals approach stimuli that predict a pleasant outcome. After the paired presentation of an odour and a reward, Drosophila melanogaster can develop a conditioned approach towards that odour. Despite recent advances in understanding the neural circuits for associative memory and appetitive motivation, the cellular mechanisms for reward processing in the fly brain are unknown. Here we show that a group of dopamine neurons in the protocerebral anterior medial (PAM) cluster signals sugar reward by transient activation and inactivation of target neurons in intact behaving flies. These dopamine neurons are selectively required for the reinforcing property of, but not a reflexive response to, the sugar stimulus. In vivo calcium imaging revealed that these neurons are activated by sugar ingestion and the activation is increased on starvation. The output sites of the PAM neurons are mainly localized to the medial lobes of the mushroom bodies (MBs), where appetitive olfactory associative memory is formed. We therefore propose that the PAM cluster neurons endow a positive predictive value to the odour in the MBs. Dopamine in insects is known to mediate aversive reinforcement signals. Our results highlight the cellular specificity underlying the various roles of dopamine and the importance of spatially segregated local circuits within the MBs. © 2012 Macmillan Publishers Limited. All rights reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84865231699&origin=inward; http://dx.doi.org/10.1038/nature11304; http://www.ncbi.nlm.nih.gov/pubmed/22810589; https://facultyopinions.com/prime/717957294#eval793461776; http://dx.doi.org/10.3410/f.717957294.793461776; https://www.nature.com/articles/nature11304; https://facultyopinions.com/prime/717957294#eval793467121; http://dx.doi.org/10.3410/f.717957294.793467121; https://dx.doi.org/10.1038/nature11304; http://europepmc.org/abstract/med/22810589; http://f1000.com/717957294#eval793461776
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